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Bohuslav Melichar Selected Research

Neopterin

4/2024Neopterin as a potential prognostic and predictive biomarker in metastatic renal cell carcinoma treated with immune checkpoint inhibitors.
2/2024Evaluation of inflammatory biomarkers and vitamins in hospitalized patients with SARS-CoV-2 infection and post-COVID syndrome.
10/2023Neopterin and kynurenine in serum and urine as prognostic biomarkers in hospitalized patients with delta and omicron variant SARS-CoV-2 infection.
7/2017Neopterin as a biomarker of immune response in cancer patients.
2/2016Citrulline as a biomarker of gastrointestinal toxicity in patients with rectal carcinoma treated with chemoradiation.
1/2016Prognostic Significance of Serum and Urinary Neopterin Concentrations in Patients with Rectal Carcinoma Treated with Chemoradiation.
11/2015Fast and sensitive HPLC method for the determination of neopterin, kynurenine and tryptophan in amniotic fluid, malignant effusions and wound exudates.
9/2014Urinary neopterin concentrations during combination therapy with cetuximab in previously treated patients with metastatic colorectal carcinoma.
9/2013Urinary neopterin concentration and toxicity of radiotherapy in patients with head and neck carcinoma during external beam radiation.
4/2012Prognostic significance of serum retinol, serum alpha-tocopherol, and urinary neopterin in patients with head and neck carcinoma treated with external beam radiation.
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Bohuslav Melichar Research Topics

Disease

93Neoplasms (Cancer)
04/2024 - 07/2002
66Renal Cell Carcinoma (Grawitz Tumor)
04/2024 - 07/2005
41Breast Neoplasms (Breast Cancer)
02/2024 - 01/2006
27Colorectal Neoplasms (Colorectal Cancer)
01/2020 - 07/2002
20Carcinoma (Carcinomatosis)
01/2021 - 07/2002
18Neoplasm Metastasis (Metastasis)
03/2024 - 10/2002
13Disease Progression
01/2023 - 01/2011
11Adenocarcinoma
04/2022 - 08/2006
11Hypertension (High Blood Pressure)
01/2021 - 02/2013
10Pancreatic Neoplasms (Pancreatic Cancer)
12/2023 - 04/2003
10Kidney Neoplasms (Kidney Cancer)
10/2022 - 11/2013
8Diarrhea
10/2021 - 11/2006
7Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2023 - 11/2006
7Ovarian Neoplasms (Ovarian Cancer)
01/2021 - 03/2007
6Ovarian Epithelial Carcinoma
01/2022 - 09/2003
6Esophageal Neoplasms (Esophageal Cancer)
01/2019 - 01/2017
5Prostatic Neoplasms (Prostate Cancer)
12/2022 - 12/2019
5Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
01/2020 - 11/2005
4Melanoma (Melanoma, Malignant)
03/2024 - 11/2015
4Stomach Neoplasms (Stomach Cancer)
10/2023 - 07/2004
4Inflammation (Inflammations)
01/2023 - 12/2016
4Peritoneal Neoplasms
09/2020 - 11/2003
4Fatigue
10/2019 - 12/2007
4Atherosclerosis
02/2016 - 11/2009
3Squamous Cell Carcinoma of Head and Neck
01/2021 - 04/2015
3Brain Neoplasms (Brain Tumor)
12/2016 - 08/2004
2Infections
02/2024 - 01/2023

Drug/Important Bio-Agent (IBA)

25Biomarkers (Surrogate Marker)IBA
04/2024 - 01/2013
24Sunitinib (Sutent)FDA Link
01/2024 - 12/2012
17Bevacizumab (Avastin)FDA Link
01/2020 - 12/2007
15pembrolizumabIBA
04/2024 - 01/2019
14NeopterinIBA
04/2024 - 07/2005
14Paclitaxel (Taxol)FDA LinkGeneric
12/2022 - 08/2004
12Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2023 - 12/2007
11Axitinib (AG 013736)IBA
12/2023 - 11/2013
11Tyrosine Kinase InhibitorsIBA
01/2023 - 01/2011
11Hormones (Hormone)IBA
03/2021 - 02/2013
11Irinotecan (Camptosar)FDA LinkGeneric
06/2015 - 07/2002
11Fluorouracil (Carac)FDA LinkGeneric
09/2014 - 07/2002
10NivolumabIBA
01/2023 - 04/2018
9LipidsIBA
01/2023 - 01/2015
9Trastuzumab (Herceptin)FDA Link
03/2021 - 09/2012
8EverolimusFDA Link
01/2021 - 08/2013
8Aromatase InhibitorsIBA
08/2016 - 08/2009
8Vitamin A (Retinol)FDA LinkGeneric
04/2012 - 11/2006
7IpilimumabIBA
02/2022 - 11/2015
7Oxaliplatin (Eloxatin)FDA LinkGeneric
03/2017 - 11/2005
7Leucovorin (Folinic Acid)FDA Link
09/2014 - 07/2002
7alpha-TocopherolFDA Link
04/2012 - 11/2007
6lenvatinibIBA
01/2024 - 11/2015
6Estrogen ReceptorsIBA
03/2021 - 06/2013
6Cetuximab (Erbitux)FDA Link
01/2021 - 04/2007
6GemcitabineFDA Link
01/2021 - 04/2003
6PlatinumIBA
01/2021 - 08/2004
6Proteins (Proteins, Gene)FDA Link
01/2019 - 01/2006
5Immune Checkpoint InhibitorsIBA
04/2024 - 01/2021
5Monoclonal AntibodiesIBA
02/2024 - 08/2006
5Cisplatin (Platino)FDA LinkGeneric
01/2023 - 07/2002
5Carboplatin (JM8)FDA LinkGeneric
12/2022 - 11/2007
5pazopanibFDA Link
02/2022 - 12/2017
5ErbB Receptors (EGF Receptor)IBA
03/2021 - 11/2008
5Capecitabine (Xeloda)FDA Link
12/2017 - 01/2012
5exemestane (Aromasin)FDA Link
08/2016 - 06/2013
5Mannitol (Osmitrol)FDA LinkGeneric
11/2014 - 08/2007
5Xylose (D-Xylose)FDA Link
11/2014 - 10/2005
5Lactulose (Duphalac)FDA LinkGeneric
11/2014 - 08/2007
4Epidermal Growth Factor (EGF)IBA
10/2023 - 01/2012
4Doxorubicin (Adriamycin)FDA LinkGeneric
01/2023 - 07/2008
4Docetaxel (Taxotere)FDA Link
12/2022 - 12/2019
4MTOR InhibitorsIBA
01/2022 - 03/2014
4Cytotoxins (Cytolysins)IBA
01/2020 - 06/2012
4Imatinib Mesylate (Gleevec)FDA Link
01/2019 - 11/2005
4Sorafenib (BAY 43-9006)FDA Link
12/2017 - 12/2012
3KynurenineIBA
02/2024 - 11/2015
3Tryptophan (L-Tryptophan)FDA Link
02/2024 - 11/2015
3cabozantinibIBA
01/2023 - 10/2020
3Alanine Transaminase (SGPT)IBA
02/2022 - 10/2019
3cabazitaxelFDA Link
10/2021 - 12/2019
3enzalutamideIBA
10/2021 - 12/2019
3abirateroneIBA
10/2021 - 12/2019
3RamucirumabIBA
12/2017 - 01/2014
3Progesterone Receptors (Progesterone Receptor)IBA
12/2017 - 02/2008
3CytokinesIBA
05/2014 - 09/2003
3Interleukin-2 (IL2)IBA
01/2009 - 10/2002
3Indicators and Reagents (Reagents)IBA
07/2008 - 07/2005
2CateninsIBA
02/2024 - 12/2023

Therapy/Procedure

89Therapeutics
04/2024 - 07/2002
43Drug Therapy (Chemotherapy)
04/2022 - 07/2002
15Immunotherapy
04/2024 - 07/2002
13Radiotherapy
02/2024 - 08/2004
12Neoadjuvant Therapy
01/2023 - 12/2008
11Nephrectomy
02/2024 - 05/2010
7Combination Drug Therapy (Combination Chemotherapy)
12/2022 - 08/2004
5Cytoreduction Surgical Procedures
07/2023 - 12/2018
4Hyperthermic Intraperitoneal Chemotherapy
01/2023 - 12/2018
4Castration
12/2022 - 12/2019
4Chemoradiotherapy
01/2017 - 11/2006
3Segmental Mastectomy (Lumpectomy)
02/2024 - 09/2013
3Brachytherapy
09/2006 - 07/2002
2Mastectomy (Mammectomy)
02/2024 - 01/2019